Multifaceted role of keratins in epithelial cell differentiation and transformation

C Dmello, SS Srivastava, R Tiwari, PR Chaudhari… - Journal of …, 2019 - Springer
… The role of keratin phosphorylation in cell transformation/progressionKeratin 8/18 is the first
pair to be expressed during … They found the expression of both K1/K10 and K4/K13 pairs in …

Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma

W Szukala, A Lichawska-Cieslar, R Pietrzycka… - Journal of Experimental …, 2021 - Springer
… the expression of MCPIP1 is related to tumor progression in … , high expression of SCCA2 was
correlated with early onset … of keratin pearls may be correlated with increased expression of …

[HTML][HTML] Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53

A Page, M Navarro, C Suarez-Cabrera, JP Alameda… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… As a first approach for studying the effect of epidermal p53 … of the expression of keratins K5,
K6, K10 and K13 and of … the changes in expression of keratins and E-cadherin in skin tumors …

Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR–ERBB2 pathway

D Bajpai, S Mehdizadeh, A Uchiyama, Y Inoue… - Oncogene, 2021 - nature.com
… PCNA expression in nucleus and elevated K13 expression in … The alteration of the keratin
pattern in the skin carcinogenesis … For tumor size (papilloma burden), we first took average of …

TRP63/TP63 loss accelerates skin tumorigenesis through activation of Wnt/β-catenin signaling

S Lakshmanachetty, V Balaiya, LK Johnson… - Journal of …, 2018 - jdsjournal.com
Early expression of type I K13 keratin in the progression of mouse skin papillomas. … In
contrast, our Trp63-ablated mice did not have an observable skin phenotype (data not shown). …

Utility of keratins as biomarkers for human oral precancer and cancer

M Vaidya, C Dmello, S Mogre - Life, 2022 - mdpi.com
… , the aberrant expression of keratin 17 and non-expression of K13 were … In addition, K8
expression was detected in the early stages of the … K8/18 is the first keratin pair expressed during …

Retinoids and squamous cell differentiation

R Lotan - Retinoids in oncology, 2020 - taylorfrancis.com
… by an increased expression of the K13 keratin (90). In … of the level of the early suprabasal
markers, keratins Kl and K10. In … , the expression of K13 increased after papilloma progress to …

[HTML][HTML] Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells

Q Li, L Yin, LW Jones, GCY Chu, JBY Wu, JM Huang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… 3-kinase (PI3K) in papilloma cells and induces the normal … prostate cancer progression
and metastasis for four reasons. … In summary, we established the first robust human prostate …

CYLD inhibits the development of skin squamous cell tumors in immunocompetent mice

JP Alameda, VA García-García, S López… - International Journal of …, 2021 - mdpi.com
… immunohistochemical staining for early (keratin K10) … K13—a keratin not expressed in
normal skin and considered a marker of tumor progression when it is aberrantly expressed in skin

Consequences of keratin phosphorylation for cytoskeletal organization and epithelial functions

MS Sawant, RE Leube - International review of cell and molecular biology, 2017 - Elsevier
… The occurrence of keratin phosphorylation in genetic skin diseases … Since the expression
of specific keratin pairs is a reliable … We first review current knowledge on the modes of keratin